N-Tense
Raintree Nutrition, 120 capsules

N-TENSE combines the rainforest's most potent and powerful plants into one synergistic formula. This proprietary and unique formula contains 50% graviola combined with 7 other plants that have similar properties and actions as graviola. Most find this unique blend of rainforest plants to have synergistic actions and provide better results than graviola alone. These power plants have been independently documented around the world with active pharmacological actions.* This formula contains: graviola, guacatonga, mullaca, vassourinha, espinheira santa, mutamba, bitter melon, and cat's claw.

Ingredients: Graviola leaf and stem, mullaca whole herb, guacatonga leaf and stem, espinheira
santa leaf, bitter melon whole herb, vassourinha leaf, mutamba bark, cat’s claw vine.

Suggested Use: Take 3-4 capsules three times daily on an empty stomach.

Contraindications:
• Not to be used during pregnancy or while breast-feeding.
• Several ingredients in this formula have demonstrated hypotensive, vasodilator, and cardiodepressant activities in animal studies. People with low blood pressure or those taking antihypertensive drugs should check with their physician before taking N-Tense and monitor their blood pressure accordingly.
• Do not take in conjuction with CoQ10. CoQ10 and other supplements which increase cellular ATP may reduce the benefits of N-Tense.

Drug Interactions: This product may potentiate antihypertensive and cardiac depressant drugs.

Other Practitioner Observations:
• Several ingredients in this formula have demonstrated significant in vitro antimicrobial properties. Chronic or long-term use of this plant may lead to die-off of friendly bacteria in the digestive tract due to its antimicrobial properties.
Supplementing the diet with probiotics and digestive enzymes is advisable if this product is used for longer than 30 days.
• Drinking plenty of water (at least 8 glasses a day) is helpful to reduce Herxheimer reactions.

Clinical Documentation and Research
This formulated product has not been the subject of any clinical research.

Available third-party documentation and clinical
research on each ingredient in this formula can be found at the Raintree website. A partial listing of published research on these ingredients is shown below:

Graviola (Annona muricata)
Liaw, C. C., et al. “New cytotoxic monotetrahydrofuran Annonaceous acetogenins from Annona muricata.” J. Nat. Prod. 2002; 65(4): 470–75.
Chang, F. R., et al. “Novel cytotoxic Annonaceous acetogenins from Annona muricata.” J. Nat. Prod. 2001; 64(7): 925–31.
Zeng, B. B., et al. “Studies on mimicry of naturally occurring Annonaceous acetogenins: Non-THF analogues leading to remarkable selective cytotoxicity against human tumor cells.” Chemistry. 2003 Jan 3; 9(1): 282-90.
Nicolas, H., et al. “Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.” J. Med. Chem. 1997; 40(13): 2102–6.
Gonzalez-Coloma, A., et al. “Selective action of acetogenin mitochondrial complex I inhibitors.” Z. Naturforsch [C]. 2002; 57(11-12): 1028-34.
Tormo, J. R., et al. “Specific interactions of monotetrahydrofuranic annonaceous acetogenins as inhibitors of mitochondrial complex I.” Chem. Biol. Interact. 1999 Nov 1; 122(3): 171-83.

Mullaca (Physalis angulata)
Chiang, H., et al. “Antitumor agent, physalin F from Physalis angulata L.” Anticancer Res. 1992; 12(3): 837–43.
Ismail, N., et al. “A novel cytotoxic flavonoid glycoside from Physalis angulata.” Fitoterapia 2001 Aug. 72(6): 676–79.
Hayashi T, A cytotoxic flavone from Scoparia dulcis L. Chem Pharm Bull (Tokyo). 1988 Dec; 36(12): 4849-51.
Chiang, H. et al. “Inhibitory effects of physalin B and physalin F on various human leukemia cells in vitro.” Anticancer Res. 1992; 12(4): 1155–62.
Kawai, M., et al. “Cytotoxic activity of physalins and related compounds against HeLa cells.” Pharmazie. 2002; 57(5): 348–50.

Guacatonga (Casearia sylvestris)
Oberlies, N. H., et al. "Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris." J. Nat. Prod. 2002; 65(2): 95-99.
Itokawa, H., et al. "New antitumor principles, casearins A-F, for Casearia sylvestris Sw. (Flacourtiaceae)" Chem. Pharm. Bull.
(Tokyo) 1990; 38(12): 3384-88.
Itokawa, H., et al. "Antitumor principles from Casearia sylvestris Sw. (Flacourtiaceae), structure elucidation of new clerodane diterpenes by 2-D NMR spectroscopy." Chem. Pharm. Bull. (Tokyo) 1988 March; 36(4): 1585-88.
Morita, H., et al. "Structures and cytotoxic activity relationship of casearins, new clerodane diterpenes from Casearia sylvestris Sw." Chem. Pharm. Bull. (Tokyo) 1991 Dec; 39(3): 693-97.
Bolzani Vda S., et al. " Search for antifungal and anticancer compounds from native plant species of Cerrado and Atlantic Forest." An. Acad. Bras. Cienc. 1999; 71(2): 181-7.

Espinheira Santa (Maytenus ilicifolia)
Itokawa, H., et al. “Antitumor substances from South American plants.” Pharmacobio. Dyn. 1992; 15(1): S-2.
Arisawa, M., et al. “Cell growth inhibition of KB cells by plant extracts.” Natural Med. 1994; 48(4): 338–347.
Shirota, O., et al. “Cytotoxic aromatic triterpenes from Maytenus ilicifolia and Maytenus chuchuhuasca.” J. Nat. Prod. 1994; 57(12): 1675–81.
Ladino, C.A., et al. “Folate-maytansinoids: target-selective drugs of low molecular weight.” Int. J. Cancer. 1997 Dec 10; 73(6):859-64.

Bitter Melon (Momordica charantia)
Claflin, A. J., et al. “Inhibition of growth and guanylate cyclase activity of an undifferentiated prostate adenocarcinoma by an extract of the balsam pear (Momordica charantia abbreviata).” Proc. Natl. Acad. Sci. 1978; 75(2): 989–93.
Terenzi, A., et al. “Anti-CD30 (BER=H2) immunotoxins containing the type-1 ribosome-inactivating proteins momordin and PAP-S (pokeweed antiviral protein from seeds) display powerful antitumor activity against CD30+ tumor cells in vitro and in SCID mice.” Br. J. Haematol. 1996; 92(4): 872–79.
Nagasawa, H., et al. “Effects of bitter melon (Momordica charantia) or ginger rhizome (Zingiber offifinale Rosc.) on spontaneous mammary tumorigenesis in SHN mice.” Am. J. Clin. Med. 2002; 30(2–3): 195–205.
Pongnikorn, S., et al. “Effect of bitter melon (Momordica charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy.” J. Med. Assoc.Thai. 2003; 86(1): 61-8.

Vassourinha (Scoparia dulcis)
Nishino, H. “Antitumor-promoting activity of scopadulcic acid B, isolated from the medicinal plant Scoparia dulcis L.” Oncology 1993; 50(2): 100–3.
Noda, Y., et al. “Enhanced cytotoxicity of some triterpenes toward leukemia L1210 cells cultured in low pH media; possibility of a new mode of cell killing.” Chem. Pharm. Bull. 1997; 45(10): 1665–70.
Zuco, V., et al. “Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells.” Cancer Lett. 2002; 175(1):17–25.
Ahsan, M., et al. “Cytotoxic diterpenes from Scoparia dulcis.” J. Nat. Prod. 2003; 66(7): 958-61.

Mutamba (Guazuma ulmifolia)
Kashiwada, Y., et al. “Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents.” J. Nat. Prod. 1992; 55(8): 1033–43.
Ito, H., et al. “Antitumor activity of compounds isolated from leaves of Eriobotrya japonica.” J. Agric. Food Chem. 2002; 50(8): 2400–3.

Cat’s Claw (Uncaria tomentosa)
Sheng, Y. “Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa.” Anticancer Res. 1998 Sep-Oct;18(5A): 3363-8.
Lemaire, I., et al. “Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa.” J. Ethnopharmacol. 1999 Feb;64(2):109-15.

*The statements contained herein have not been evaluated by the Food and Drug Administra tion.
This product is not intended to treat, cure, or prevent any disease.