What Is It?

l-Arginine is a safe, versatile amino acid supporting protein synthesis and serving as a precursor of nitric oxide.*

Uses For l-Arginine

Cardiovascular Health: In the body, the metabolism of l-arginine leads to the formation of nitric oxide. Arginine-derived nitric oxide is an important catalyst for healthy dilation of blood vessels, circulation, and blood flow. In a prospective, double-blind trial, l-arginine supplementation supported healthy endothelial function in blood vessels of male volunteers. In other studies, l-arginine promoted healthy platelet function and enhanced exercise tolerance. Additional trials indicate that l-arginine may support healthy lipid metabolism and moderate lipid peroxidation, enhancing its cardiovascular support properties.*

Support For Immune Function And Healthy Tissues: Arginine has demonstrated immuno-stimulatory activity and may promote the utilization of nitric oxide by scavenger cells for defense mechanisms. Enhancement of immune messenger compounds has also been observed in several studies with l-arginine. In a study involving elderly individuals, l-arginine facilitated healthy tissue recovery, accelerated tissue repair and supported immune health.*

Male Sexual Function: In men with low urinary nitric oxide values, l-arginine may support healthy sexual performance. Some but not all research involving l-arginine supplementation for sperm motility have produced positive results.* Growth Hormone Support: Arginine plays a role in the synthesis of hormones such as insulin and growth hormone, and has demonstrated the potential to support glucose metabolism and growth hormone production respectively.*

Memory: Nitric oxide is also a mediator of neurotransmission in the brain, supporting memory under the circumstances of reduced intracellular arginine.*

Free Base vs. HCL

Recommendations

Vitamin Research recommends 2-6 capsules per day, on an empty stomach (e.g., between meals).

Are There Any Potential Side Effects Or Precautions?

If pregnant or lactating, consult your physician before taking this product. Because of its effect on nitric oxide production, l-arginine is theoretically best avoided by individuals with migraines, depression, autoimmune disorders, and kidney or liver disease. Arginine is contraindicated for individuals with the herpes virus.

Are There Any Potential Drug Interactions?

At this time, there are no known adverse reactions when taken in conjunction with medications.

References:

1. Siani A et al. Blood pressure and metabolic changes during dietary Larginine supplementation in humans. Am J Hyperten 2000 May;13(5 Pt 1):547- 51.

2. Wolf A, Zalpour C, Theilmeier G, et al. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J Am Coll Cardiol1997;29:479-85.

3. Sozykin Av et al. Effect of L-arginine on platelet aggregation, endothelial function and exercise tolerance in patients with stable angina pectoris. Ter Arkh.2000;72(8):24-7.

4. Bednarz B, et al. Effects of oral L-arginine supplementation on exerciseinduced QT dispersion and exercise tolerance in stable angina pectoris. Int J Cardiol.2000 Sep 15;75(2-3):205-10.

5. Adams MR et al. Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis. 1997 Mar 21;129(2):261-9.

6. Kirk SJ, Hurson M, Regan MC, et al. Arginine stimulates wound healing and immune function in elderly human beings. Surgery1993;114:155-60.

7. Besset A, Bonardet A, Rondouin G, et al. Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man. Acta Endocrinol1982;99:18-23.

8. Chen J et al. Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a doubleblind, randomized, placebo-controlled study. BJU Int.1999 Feb;83(3):269-73.

9. Kuiper MA et al. Decreased cerebrospinal fluid nitrate levels in Parkinson's disease, Alzheimer's disease and multiple system atrophy patients. J Neurol Sci.1994 Jan;121(1) 46-9.

10. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes, Inc.

2–6 capsules per day, in divided doses, between meals.